Unless you have a large amp, there really is no point - it's not very expensive but getting the cables through the doors is a PROPER PITA!
So no, not "worth" it. However, larger cables = less resistances, which will make it sound better. But whether you'd notice it, I doubt it...
Having said all that, I've done it. I just like using OTT speaker wire everywhere - all the mids in my car are wired up with 2.5mm˛ cable as is my 500w home cinema system downstairs.
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